袭荣文博士
- 基本信息
- 教育经历
- 工作经历
- 研究概述
- 发表文章
袭荣文 博士
北京科学生命JDB电子(中国)资深研究员
Rongwen Xi, Ph.D. Investigator, NIBS, Beijing, China
Phone：010-80726688-8510
Fax： 010-80723249
E-mail：xirongwen@kbryl.com
教育经历
Education
|
2002 |
美国肯塔基州大学生物学博士 |
|
|
Ph.D. in Biology, 2002，University of |
|
1998 |
上海医科大学 理科硕士 |
|
|
Master in Science, 1998，Shanghai Medical University, China |
|
1995 |
滨州医学院 临床医药学学士 |
|
|
B.S., Department of Clinical Medicine, 1995，Binzhou |
工作经历
Professional Experience
北京科学生命JDB电子(中国)资深研究员
Investigator, National Institute of Biological Sciences, Beijing, China
2011-2018
北京科学生命JDB电子(中国)高级研究员
Associate Investigator, National Institute of Biological Sciences, Beijing, China
北京科学生命JDB电子(中国)研究员
Assistant Investigator, National Institute of Biological Sciences, Beijing, China
美国思达沃医学JDB电子(中国)博士后
Postdoctoral Research Associate with Dr. Ting Xie at the Stowers Institute for Medical Research, USA
美国肯塔基州大学生物系助教，助研
Teaching Assistant, Research Assistant at the Department of Biology,University of Kentucky, USA
2018-
2006-2011
2003-2006
1998-2002
研究概述
成体干细胞长期存在于多种组织和器官内，顺利获得不断的自我更新和分化，维持组织细胞的新旧更替。干细胞功能的失调可能导致癌症或退行性病变等疾病的发生，但我们对干细胞增殖和分化时细胞的命运抉择等行为的分子调控机制还没有清楚的理解。我们结合相对简单的遗传模式生物果蝇及哺乳动物模型，以肠道干细胞为主要研究对象，研究干细胞自我更新和多个细胞谱系分化过程中命运决定的内源性机制及环境调控机制，及肠上皮细胞的分化和功能调节机制及它们在脑-肠-肠道菌群轴中所扮演的角色。我们的研究将最终为肠道肿瘤、代谢性疾病等肠道相关疾病的防治给予理论依据和试验基础。
Research Description
Adult stem JDB电子(中国)s reside in many tissues and organs and have the ability to self-renew indefinitely and generate progenies that differentiate and replace aged and damaged JDB电子(中国)s. Dysregulation of stem JDB电子(中国)s is intimately associated with various types of diseases such as cancer and degenerative diseases, but the molecular mechanisms regulating stem JDB电子(中国) fate decisions during self-renewal and JDB电子(中国) lineage differentiation are in general poorly understood. Using intestinal stem JDB电子(中国) systems in both flies and mice, we aim to understand the intrinsic and extrinsic mechanisms underlying stem JDB电子(中国) fate decisions, and the differentiation and functional regulation of intestinal JDB电子(中国)s and their roles played in the brain-gut-microbiota axis. Our research should ultimately bring new mechanistic insights into intestinal tumors and other digestive and metabolic diseases and pave the way to new treatments.
Publications:
1. Zhu G, Hu J, Xi R* (2021). The JDB电子(中国)ular niche for intestinal stem JDB电子(中国)s: a team effort. JDB电子(中国) Regen. 10(1):1.
2. Shi J, Jin Z, Yu Y, Zhang Y, Yang F, Huang H, Cai T, Xi R* (2021). A Progressive Somatic JDB电子(中国) Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary. Curr Biol. 31(4):840-852.e5.
3. Jin Z, Chen J, Huang H, Wang J, Lv J, Yu M, Guo X, Zhang Y, Cai T, Xi R*(2020). The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level. JDB电子(中国) Rep. 31(8):107683.
4. Kobayashi M, Lin Y, Mishra A, Shelly C, Gao R, Reeh CW, Wang PZ, Xi R, Liu Y, Wenzel P, Ghosn E, Liu Y, Yoshimoto M (2020). Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes. J Immunol. 204(12):3262-3272.
5. Li Z, Guo X, Huang H, Wang C, Yang F, Zhang Y, Wang J, Han L, Jin Z, Cai T, Xi R*(2020). A Switch in Tissue Stem JDB电子(中国) Identity Causes Neuroendocrine Tumors in Drosophila Gut. JDB电子(中国) Rep. 30(6):1724-1734.e4.
6. Guo X, Yin C, Yang F, Zhang Y, Huang H, Wang J, Deng B, Cai T, Rao Y, Xi R* (2019). The JDB电子(中国)ular Diversity and Transcription Factor Code of Drosophila Enteroendocrine JDB电子(中国)s. JDB电子(中国) Rep. 29(12):4172-4185.e5.
7. Guo X, Huang H, Yang Z, Cai T, Xi R* (2019). Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem JDB电子(中国) Differentiation in Drosophila. Stem JDB电子(中国) Reports. 12(5):1007-1023
8. Yang F*, Quan Z, Huang H, He M, Liu X, Cai T, and Xi R* (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Elife 2019 Jan 16;8. pii: e40806.
9. Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G (2018). Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants. Dev JDB电子(中国). pii: S1534-5807(18)31031-1.
10. Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R* (2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine JDB电子(中国) pair specification from self-renewing intestinal stem JDB电子(中国)s. Nat JDB电子(中国) Biol. 20(2):152-161
11. Yin C, Xi R* (2018). A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem JDB电子(中国) Enteroendocrine Commitment in Drosophila. Stem JDB电子(中国) Reports. 9;10(1):43-57.
12. Huang C, Yang F, Zhang Z, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R*, Zhu B* (2017). Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila. Nat Commun. 8(1):1649.
13. Liu X, Wei W, Li X, Shen P, Ju D, Wang Z, Zhang R, Yang F, Chen C, Cao K, Zhu G, Chen H, Chen L, Sui J, Zhang E, Wu K, Wang F, Zhao L, Xi R* (2017). BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. pii: S0016-5085(17)35976-0.
14. Li Y*, Pang Z, Huang H, Wang C, Cai T, Xi R* (2017). Transcription Factor Antagonism Controls Enteroendocrine JDB电子(中国) Specification from Intestinal Stem JDB电子(中国)s. Sci Rep. 20;7(1):988.
15. Yang F, Xi R* (2017). Silencing transposable elements in the Drosophila germline. JDB电子(中国) Mol Life Sci. 74(3):435-448.
16. Chen J., Li J., Huang H. and Xi R*. (2016). Gene Expression Analysis of Sorted JDB电子(中国)s by RNA-seq in Drosophila Intestine. Bio-protocol 6(24): e2079. DOI: 10.21769/BioProtoc.2079
17. Li X, Yang F, Chen H, Deng B, Li X, Xi R* (2016). Control of germline stem JDB电子(中国) differentiation by polycomb and trithorax group genes in the niche microenvironment. Development. 143(19):3449-3458 pii: dev.137638.
18. Chen J, Xu N, Huang H, Cai T, Xi R* (2016). A feedback amplification loop between stem JDB电子(中国)s and their progeny promotes tissue regeneration and tumorigenesis. Elife. 5. pii: e14330. doi: 10.7554/eLife.14330
19. Wang C, Xi R* (2015). Keeping intestinal stem JDB电子(中国) differentiation on the Tramtrack. Fly (Austin). 14:0.
20. Hu Z, Hu Y, Liu X, Xi R, Zhang A, Liu D, Xie Q, Chen L (2015). Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor. Oncotarget. 6(31):31628-39
21. Wang C, Guo X, Dou K, Chen H, Xi R* (2015). Ttk69 acts as a master repressor of enteroendocrine JDB电子(中国) specification in Drosophila intestinal stem JDB电子(中国) lineages. Development 142(19):3321-31
22. Yang F, Zhao R, Fang X, Huang H, Xuan Y, Ma Y, Chen H, Cai T, Qi Y, Xi R* (2015). The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep. 16(8):965-74
23. Wang C, Guo X, Xi R* (2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple JDB电子(中国) lineage differentiation of Drosophila gastric stem JDB电子(中国)s. JDB电子(中国) Research 24(5):610-27
24. Quan Z, Sun P, Lin G, Xi R* (2013). TSC1/2 regulates intestinal stem JDB电子(中国) maintenance and lineage differentiation via Rheb-TORC1-S6K but independent of nutrition status or Notch regulation. J JDB电子(中国) Sci. 126:3884-92
25. Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R* (2013). APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression. Developmental Biology 378(2):122-40
26. Lin G, Zhang X, Ren J, Pang Z, Wang C, Xu N, Xi R* (2013). Integrin signaling is required for maintenance and proliferation of intestinal stem JDB电子(中国)s in Drosophila. Developmental Biology 377(1):177-87
27. Wen P, Quan Z, Xi R* (2012). The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. Developmental Dynamics 241(3):455-64
28. Xu N, Wang SQ, Tan D, Gao Y, Lin G, Xi R* (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem JDB电子(中国)s. Developmental Biology 354(1):31-43
29. Su Y, Deng B, Xi R* (2011). Polycomb group genes in stem JDB电子(中国) self-renewal: a double-edged sword. Epigenetics. 6(1):16-9.
30. Sun P, Quan Z, Zhang, B, Wu T, Xi R* (2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem JDB电子(中国)s by preventing differentiation. Development 137(15):2461-9
31. Wen P, Sun P, Xi R* (2010). Stem JDB电子(中国) niche (book chapter) in “Regenerative Medicine – From Protocol to Patient”. The Springer Press.
32. Li X, Han Y, Xi R* (2010). Polycomb group genes Psc and Su(z)2 restrict follicle stem JDB电子(中国) self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes & Development 24(9):933-46.
33. Zhao R, Xi R* (2010). Stem JDB电子(中国) Competition for Niche Occupancy: Emerging Themes and Mechanisms. Stem JDB电子(中国) Rev. 6(3):345-50
34. Lin G, Xu N, Xi R* (2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem JDB电子(中国)s. J Mol JDB电子(中国) Biol 2(1): 37-49.
35. Xi, R* (2009). Anchoring stem JDB电子(中国)s in the niche by JDB电子(中国) adhesion molecules. JDB电子(中国) Adh Migr 3(4): 396-401.
36. Lin G, Xi R* (2008) Intestinal stem JDB电子(中国), muscular niche and wingless signaling. Fly (Austin). 2(6): 310-2.
37. Lin G, Xu N, Xi R* (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem JDB电子(中国)s. Nature 455(7216):1119-23.
38. Zhao R, Xuan Y, Li X, Xi R* (2008). Age-related changes of germline stem JDB电子(中国) activity, niche signaling activity and egg production in Drosophila. Aging JDB电子(中国) 7(3):344-54
39. Xi R, Xie T (2005). Stem JDB电子(中国) self-renewal controlled by chromatin remodeling factors. Science 310(5753):1487-9.
40. Xi R, Doan C, Liu D, Xie T (2005). Pelota controls self-renewal of germline stem JDB电子(中国)s by repressing a bam-independent differentiation pathway. Development 132(24):5365-74.
41. Xi R, Kirrily D, Xie T (2005). Molecular mechanisms controlling germline and somatic stem JDB电子(中国)s: similarities and differences (review). Curr Opin Genet Dev. 15(4):381-7.
42. Rawlings JS, Rennebeck G, Harrison SM, Xi R, Harrison DA (2004). Two Drosophila Suppressors of Cytokine Signaling (SOCS) differentially regulate JAK and EGFR pathway activities. BMC JDB电子(中国) Biol. 15;5(1):38.
43. Song X, Wong, MD, Kawase E, Xi R, Ding BC, McCarthy J, Xie T (2004). BMP signaling from the niche directly represses the transcription of a differentiating gene, bag of marbles, in the germline stem JDB电子(中国)s of Drosophila ovary. Development 131(6):1353-64.
44. Xi R, McGregor JR, Harrison DA (2003). A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Developmental JDB电子(中国) 4(2):167-77.
45. McGregor JR, Xi R, Harrison DA (2002). JAK signaling is somatically required for follicle JDB电子(中国) differentiation in Drosophila. Development 129(3):705-17.
